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ISBN-10: 0387587888

ISBN-13: 9780387587882

ISBN-10: 3540587888

ISBN-13: 9783540587880

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Here the polyanions gave relatively mild immunoresponse [459,492], polycations gave undesirable effects arising from ionic interactions with cell surfaces [494, 495]. When similar polyelectrolyte complexes were used as drug carriers [336,496-498], steric barriers to antigenicity and increased circulation times 42 A. B. Scranton et al. were observed. Reductions in interactions between carriers and proteins and cells of the vasculature gave rise to increased avoidance of mononuclear phagocytic system.

L 41 Fig. 2. Swelling kinetics of 8 caffeine-loaded methyl methacrylate/iV,Ai-dimethylaminoethyl methacrylate copolymer hydrogels. (D) pH 3, (A) pH 5. Siegel RA, Falamarzian M, Firestone BA, Moxley BC (1988) J Contr Rel 8: 179. Reproduced with permission *i a O« 250 300 TIME(min) 28 A. B. Scranton et al. for the lower permeability of synthetic progestin than that of progesterone through methacrylic films [329]. Furthermore, the effects of plasticizers on compatibility, mechanical properties and adhesion strength of drug-free Eudragit E films were elucidated by Lin et al.

31. 32. 33. 34. 35. 45 Klier J, Scranton AB, Peppas NA (1990) Macromolecules 23: 4944 Kudo S, Konno M, Saito S (1992) Makromol Chem Rapid Commun 13: 545 Schoo HFM, Challa G (1992) Macromolecules 25: 1663 Akashi M, Takemoto K (1990) Advances in Polym Sei 97: 107 Peppas NA, Khare AR (1993) Advanced Drug Del Rev 11: 1 Trijasson P, Pith T, Lambía M (1990) Makromol Chem Macromol Symp 35/36: 141 Hunkeler D, Hamielec AE (1992) In: Harland RS, Prud'homme RK (eds) Polyelectrolyte gels, ACS Symposium Series 480 American Chemical Society, Washington, DC, p 24 36.

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Biopolymers / 2

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