By Lathrop R. H., Rogers Jr R. G., Smith T. F.
A rigorous Bayesian research is gifted that unifies protein sequence-structure alignment and popularity. Given a series, particular formulae are derived to choose (1) its globally so much possible middle constitution from a constitution library; (2) its globally such a lot possible alignment to a given center constitution; (3) its such a lot possible joint center constitution and alignment selected globally around the whole library; and (4) its so much possible person segments, secondary constitution, and super-secondary constructions around the whole library. The computations concerned are NP-hard within the common case (3D-3D). quick specific recursions for the constrained series singleton-only (1D-3D) case are given. Conclusions contain: (a) the main possible joint center constitution and alignment isn't inevitably the main possible alignment of the main possible middle constitution, yet quite maximizes the manufactured from center and alignment possibilities; (b) use of a sequence-independent linear or affine hole penalty can result within the highest-probability threading no longer having the bottom rating; (c) settling on the main possible middle constitution from the library (core constitution choice or fold reputation simply) consists of evaluating percentages summed over all attainable alignments of the series to the center, and never evaluating person optimum (or near-optimal) sequence-structure alignments; and (d) assuming uninformative priors, middle constitution choice is corresponding to evaluating the ratio of 2 international capability.
Read or Download A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment PDF
Similar biotechnology books
The economic convention on info Mining ICDM-Leipzig was once the fourth assembly in a chain of annual occasions which begun in 2000, prepared through the Institute of desktop imaginative and prescient and utilized machine Sciences (IBaI) in Leipzig. The undertaking of the convention is to assemble researchers and folks from with a view to speak about jointly new developments and purposes in facts mining.
People face the problem of manufacturing adequate nutrition to fulfill the calls for imposed by means of financial, organic and agricultural components: emerging inhabitants; emerging source of revenue; and an expectation of upper caliber nutrition and a extra assorted nutrition; reducing quantity of land on hand for meals construction; reducing environmental influence of agricultural practices and keeping biodiversity.
A state-of-the-art examine the applying of micro and nanotechnologies in regenerative medicineThe zone on the interface of micro/nanotechnology and stem cells/tissue engineering has obvious an explosion of task in recent times. This booklet offers a much-needed evaluate of those interesting advancements, overlaying all points of micro and nanotechnologies, from the elemental ideas to the most recent learn to purposes in regenerative medication.
- Biotechnology : a multi-volume comprehensive treatise / 4 Measuring, modelling and control
- Cell Culture Engineering
- Antibody Drug Discovery
- Environmental Biotechnology: Theory and Application
- The Business of Bioscience: What goes into making a Biotechnology Product
Additional info for A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment
Mol. Biol. 268, 209-225. , A. Kolinski and A. R. Ortiz (1997). MONSSTER: A method for folding globular proteins with a smal1 number of distance restraints. 7. MoZ. BioZ. 265, 217-241. Smith, T. , R. H. Lathrop and F. E. Cohen (1996). The identification of protein functional patterns, in Integrative Approaches to Molecular Biology, J. Collado-Vides, B. Magasanik, B. and CT. F. Smith (Eds), Cambridge, MA: MIT Press, pp. 29-61. Smith, T. , L. Lo Conte, J. Bienkowska, R. G. Rogers Jr, C. Gaitatzes and R.
Jones, D. , W. R. Taylor and J. M. Thornton (1992). A new approach to protein fold recognition. Nature (London) 358, 8689. Jones, D. T. and J. M. Thornton (1993). Protein fold recognition. J. Computer-Aided Mol. Design. 7, 439-456. Jones, D. T. and J. M. Thornton (1996). Potential energy functions for threading. Current Opinion in Structural Biol. 6, 210-216. , J. Skolnick and A. Godzi (1996). An algorithm for prediction of structural elements in small proteins, in Proc. PaciJc Symp. on Biocomputing ‘96, L.
Wilbur, W. , F. Major, J. Spouge and S. Bryant (1996). The statistics of unique native states for random peptides. Biopolymers 38 447459. Wilmanns, M. and D. Eisenberg (1993). Three-dimensional profiles from residue-pair preferences: Identification of sequences with #J/a-barrel fold. Proc. Natl Acad. Sci. A Bayes-optimal USA Wodak, Opinion 90, 1379-1383. S. J. and M. J. Rooman in Structural Biol. Sequence-structure (1993). Generating 1071 Theory and testing protein folds. Current 3, 247-259. Xu, Y.
A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment by Lathrop R. H., Rogers Jr R. G., Smith T. F.